Nanotechnology offers major opportunities in the area of cancer diagnostics and treatment. Working at the interface of chemistry and physics, we are pioneering new and exciting approaches to targeted and triggered therapeutics and cancer-specific imaging. Our nanomaterials are built from clinically approved components to enable integration into clinical practice. Clinically used radiation is employed for triggering of chemo- photo- and gene therapies, including CRISPR. These are developed and tested in cancer models including three-dimensional tissue-engineering constructs.