The future weaver
Tucked away in a small room in UNSW’s Graduate School of Biomedical Engineering sits a 19th century–era weaver’s wooden loom. Operated by punch cards and hooks, the machine was the first rudimentary computer when it was unveiled in 1801.
While on the surface it looks like a standard Jacquard loom, it has been enhanced with motherboards integrated into each of the loom’s five hook modules and connected to a computer. This state-of-the-art technology means complex algorithms control each of the 5,000 feed-in fibres with incredible precision.
That capacity means the loom can weave with an extraordinary variety of substances, from glass and titanium to rayon and silk, a development that has attracted industry attention around the world.
The interest lies in the natural advantage woven materials have over other manufactured substances. Instead of manipulating material to create new shades or hues as in traditional weaving, the fabrics’ mechanical properties can be modulated, to be stiff at one end, for example, and more flexible at the other.
“Instead of a pattern of colours we get a pattern of mechanical properties,” says Melissa Knothe Tate, UNSW’s Paul Trainor Chair of Biomedical Engineering. “Think of a rope; it’s uniquely good in tension and in bending. Weaving is naturally strong in that way.”
While the loom’s materials have countless potential manufacturing applications – one tyremaker believes a titanium weave could spawn a new generation of thinner, stronger and safer steel-belt radials – Professor Knothe Tate is more interested in the machine’s human potential.
She believes it is possible, for example, to weave biological tissues – essentially human body parts – in the lab to replace and repair our failing joints. What’s more, she is convinced that one day those same parts will be woven inside the body.
“It’s always been a dream of mine to teach cells to weave their own repair,” Knothe Tate says. It would be a “living loom” and the ultimate disruptive technology, “but we’re not there yet, so we want to learn from the cells and begin the process in the lab”.
“Weaving is an ancient art but if you bring the newest technology to it, I think some pretty exciting things can happen.”
Biomedical “sweet spot”
Even in a discipline where the name is derived from the Latin ingenium, meaning “cleverness” and ingeniare, meaning “to contrive or devise”, UNSW’s biomedical engineers are pushing boundaries. Down the hall from Knothe Tate’s office atop the Gordon Samuels Building, a team led by Scientia Professor Nigel Lovell and Professor Gregg Suaning is designing a bionic eye.
Nearby Dr Lauren Kark is engineering a new generation of prosthetic limbs, while other researchers are developing biomimetic-inspired materials to regenerate tissue.
And in UNSW’s Wainwright Analytical Centre and the Biomedical Imaging Facility are some of the world’s most advanced microscopes, capable of capturing the inner workings of a single living cell.
Knothe Tate believes biomedical engineering is on the cusp of enormous advances. “I always talk about being in the sweet spot. It’s like there’s a wave and biomed is at the forefront,” she says.
The interface of mechanics and physiology is the focus of Knothe Tate’s work. In March, she travelled to the United States to present another aspect of her work at a meeting of the international Orthopedic Research Society in Las Vegas. That project – which has been dubbed “Google Maps for the body” – explores the interaction between cells and their environment in osteoporosis and other degenerative musculoskeletal conditions such as osteoarthritis.
Using previously top-secret semiconductor technology developed by optics giant Zeiss, and the same approach used by Google Maps to locate users with pinpoint accuracy, Knothe Tate and her team have created “zoomable” anatomical maps from the scale of a human joint down to a single cell.
She has also spearheaded a groundbreaking partnership that includes the Cleveland Clinic, and Brown and Stanford universities to help crunch terabytes of data gathered from human hip studies – all processed with the Google technology. Analysis that once took 25 years can now be done in a matter of weeks, bringing researchers ever closer to a set of laws that govern biological behaviour.
Her vision was a key reason for UNSW and the Paul Trainor Foundation bringing Knothe Tate to Australia to take up the inaugural Paul Trainor Chair in Biomedical Engineering, named after the father of Australia’s medical devices, who died in 2006.
“Paul Trainor was the veritable founder of the biomedical industry in Australia. He was responsible for developing and championing the cochlear implant and cardiac pacemakers, among other technologies, and a big part of my position here at UNSW is to reinvigorate the industry he helped create, and to build on it even more,” Knothe Tate says.
Head of School, Professor John Whitelock, says the future of biomedical engineering relies on innovative academics like Knothe Tate crossing boundaries and commercialising their discoveries. “Just two years into her role, Melissa is pushing boundaries and has already patented several new technologies. She’s more than proved she is the right person to continue Paul Trainor’s legacy,” he says.
Not your average engineer
The daughter of an electrical engineer who led the US Navy’s nuclear program in EMP, the electromagnetic pulse aftermath of nuclear blasts, Knothe Tate had an itinerant childhood, following her father as he moved between postings.
Like her dad, she was fascinated with science and technology from an early age. Curious about temperature’s effects on growth, the 12-year-old Knothe Tate asked for an incubator and cleared space in the family fridge to experiment with chicken embryos.
She spent her spare high school hours shadowing doctors and penned curious adolescent letters to surgeons about the ethical dilemmas of breast augmentation and cosmetic surgery. “I thought I was going to be a reconstructive surgeon for children with congenital malformations, but I just don’t like hospitals,” she admits.
While hospitals proved a no-go zone, Knothe Tate still held a love for medicine’s impact on human life. Moulding her own biomedical engineering degree long before the discipline existed, Knothe Tate enrolled at Stanford in separate degrees in biology and mechanical engineering, working three jobs for financial support.
Though majoring in science, Knothe Tate was also passionate about philosophy and art, with a particular interest in German language and culture. Drawn to Europe, she packed up and headed to the Swiss Federal Institute of Technology – ETH Zurich – to complete her doctoral studies. It would be a seminal experience, opening her world to new opportunities and ways of thinking – as well as bringing husband, Ulf Knothe, with whom she’s had a daughter, into her life.
Knothe Tate keeps a picture of her Swiss graduating class on her desk. It features just two women: “One is the secretary of the school and one is me.”
Today, half of Knothe Tate’s research team is women, a ratio reflected in the Graduate School of Biomedical Engineering as a whole. “It’s a huge change, and it’s one of the things that’s most encouraging,” she says.
From Zurich, Knothe Tate and Ulf, an orthopaedic surgeon who collaborates with his wife on many of her studies, were recruited to the Cleveland Clinic. Colleagues thought she was crazy to turn down a plum Swiss post – a Gemachtesbett or “made bed” in terms of academia – for the north-eastern US. “I always pick the challenge, I think it’s sort of hardwired. I just needed to find my own path, a new path,” she says.
It was a formative time that brought her out of the lab and into contact with patients. “You see all the families, it’s so present,” she says of her clinical role. “As an engineer I had the feeling that what we were doing was really important and we’d better make sure it’s relevant for patients. It had a huge impact on my future research directions.”
Weaving the future
In her UNSW office, Knothe Tate’s desk is surrounded by bones. The walls, too, are filled with framed images of the inner workings of muscles, joints and ligaments. Captured by some of the world’s most sophisticated fluorescence and electron microscopes, the multicoloured architecture is scattered on black backgrounds like constellations.
On her computer screen, a research paper displays a cross-section of a sheep’s femur, together with second harmonic and multiphoton images that capture the distribution of the section’s structural proteins. “What you see is the weave of the cells that inhabit our bodies,” Knothe Tate says, pointing to the fluorescent green, yellow and orange interplay of fibres between bone and muscle.
Our bones, she explains, are super strong, able to bear incredible weight because they contain the protein collagen (without it they would be brittle like chalk). They are covered by a sleeve of protective tissue called the periosteum.
One of periosteum’s unique qualities is its toughness. Another protein, elastin, makes it, “stretchy like a rubber band”. But due to the collagen, “it’s a rubber band that doesn’t break”. “It’s only 500 microns thick; so it’s fascinating to think this soft fabric – our body’s fabric – imbues our bones with such super strength,” Knothe Tate says.
As a composite structure, periosteum has emergent properties – its strength lies in more than the sum of its parts. These “smart” properties are what Knothe Tate is reproducing on her loom.