Mathematical Models and Methods in Drug Delivery Systems
Dr. Giuseppe Pontrelli, Instituto per le Applicazioni del Calcolo-CNR, Rome, Italy
—All Welcome —
The topic of controlled drug release has received much attention in recent years, for example in the design of tablets and in local drug delivery devices such as stents, transdermal patches, therapeutic contact lenses and orthopaedic implants. We have developed a series of models for such devices to describe drug release from a polymeric platform, mass transport in surrounding biological tissues and fully coupled models of them. In this talk we present an overview of mathematical models of drug delivery from a durable polymer coated device, and in particular for a composite micro-capsule. Through semi-analytical and numerical solutions, we demonstrate how the release rate may in principle be controlled by varying the underlying microstructure of polymer core or the properties of the coating. Our results show the role of the relevant material parameters used to tailor the release curves to a given application.
Giuseppe Pontrelli is a senior researcher at Istituto per le Applicazioni del Calcolo of CNR in Rome. His research interests include applied mathematics, continuum mechanics and numerical analysis with application in biofluid dynamics, physiological flows at micro and nanoscale, mass transport, drug delivery in porous materials. Over the years, he has worked on many research projects and developed, with a multi-disciplinary approach, mathematical models and computational methods for complex systems related to health. He is the author of over 80 papers in international scientific journals and book chapters.